Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten consumption, occurring in genetically predisposed individuals.1~3 It is caused by a permanent intolerance to gluten and specifically to its proteic fragment called gliadine. The ingestion of such protein for in people  with genetic predisposition, induce a severe injury of the intestinal mucosa that is histologically characterized by one hyperplasia of cryptas with  total or subtotal atrophy of the intestinal microvilli. Though the definitive diagnosis of the celiac disease is based in characteristic histological  changes observed in intestinal biopsies, the serological tests, such as the detection of antibodies anti-tTG and anti-endomysium, represent  methods of analyses cheaper and less invasive to the detection of the disease.

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